Could Worms In Your Gut Cure Your Allergies? | KUOW News and Information

Could Worms In Your Gut Cure Your Allergies?

Aug 12, 2016
Originally published on August 12, 2016 9:28 am

When you first meet Moises Velasquez-Manoff, the first thing you notice is his hair — or the lack of it.

He's completely bald.

"At age 11, I developed this condition, called alopecia areata, where I lost my hair," says Velasquez-Manoff, a science writer in Berkeley, Calif. "It started in patches, but eventually I lost it all."

A few years ago Velasquez-Manoff was working on a book about autoimmune diseases, like allergies, asthma, Crohn's disease and alopecia. He talked to many people who were using an unlikely tool to treat their problems: parasitic worms that live in your gut — permanently.

The worms were getting rave reviews. "People were saying, 'I had absolutely zero symptoms. And my disease went into remission!'" Velasquez-Manoff says.

So he started to wonder: Could these worms cure his alopecia? Maybe his hay fever, too?

He went down to Mexico, bought 30 hookworms and let the larvae infect him.

Hookworm larvae are microscopic. But they have little spikes that puncture the skin and allow the larvae to burrow inside you. Then the critters head straight for a capillary.

"They basically ride your bloodstream back through your heart, into your lungs," where they hang out for a while, Velasquez-Manoff says.

Then the larvae crawl out of the lung through your stomach and into the small intestine — where they bite onto the intestinal wall and start sucking blood — a few drops a day.

At that point, the worms do something amazing: They suppress the immune system, says P'ng Loke, an immunologist at the New York University School of Medicine.

"That's the really fascinating thing," he says. You see, the worms don't shut down the immune system completely — just enough so that the immune cells won't attack the worm.

But this can help with something else. It can keep the immune system from getting out of control and attacking the body.

"If you think about it, the worst thing that you want is an immune system that's out of control," Loke says.

Why? Because that's when you get autoimmune problems. So the hypothesis is that intestinal worms could possibly reverse these problems, by damping down the immune system.

The idea was so promising, that back in 2011 a pharmaceutical company decided to test it in clinical trials. Coronado Biosciences put together about six large studies.

The first study to finish was a big one in Europe that looked to see if pig whipworms helped with Crohn's disease.

The bottom line: "The proportion of patients who improved with the worms was no different than the proportion of patients who were improved with placebo," says Dr. Stephen Hanauer at Northwestern University Feinberg School of Medicine, who was involved with one trial.

The whipworms were so ineffective at stopping Crohn's disease that Coronado canceled its other trials. The company's stock plummeted. And eventually the company changed its name and focus.

Other trials with worms haven't gone so well either, says Hanauer. "The controlled trials, thus far, in a variety of different diseases including childhood allergies and asthma have not been positive."

It's unclear why the worms haven't worked in these trials, Loke says. It could be that the whipworm larvae weren't prepared correctly. Or that the worms work for some people but not others. It may depend on a person's genes.

Back in Berkeley, Velasquez-Manoff thought he might one of the lucky ones.

A little while after he took the hookworms, his hay fever disappeared.

"Like just gone, gone, gone," he says.

And his hair?

"Then I had like, little bit of peach fuzzy hair growing here and there on my body," Velasquez-Manoff says.

But then the tide turned. "Suddenly it's like one day, the whole thing reversed."

His hay fever came back. The hair didn't grow anymore.

And having worms in his body wasn't pleasant. At first, he had diarrhea and cramps. That got better. But even months later, he still felt kind of bad.

"I never got back to feeling completely normal for that year [that the worms were inside]," Velasquez-Manoff says.

He says the benefits of the worms definitely didn't outweigh the bad side effects. And he would never try treating his alopecia or hay fever with them again.

"The way I thought of it was, would I give this to my kids? And the answer is pretty easily and obviously: Hell no," Velasquez-Manoff says. "I wouldn't want them to feel this way."

Copyright 2017 NPR. To see more, visit http://www.npr.org/.

RENEE MONTAGNE, HOST:

Now we turn to an unusual trend in medicine. People are trying to treat autoimmune problems, like asthma, allergies and Crohn's disease, with an unlikely tool - worms that live in your gut permanently. And perhaps this is a good moment to put down your cereal spoon, as NPR's Michaeleen Doucleff reports.

MICHAELEEN DOUCLEFF, BYLINE: Moises Velasquez-Manoff is a science writer in Berkeley. And for years, people have told him how great worms are for treating horrible autoimmune diseases. People said they were completely cured. So Velasquez-Manoff was curious.

MOISES VELASQUEZ-MANOFF: So, like, what did people feel like - is what I wanted to know - with these things living in their body?

DOUCLEFF: Oh, I forgot to mention, Velasquez-Manoff has no hair. He has an autoimmune disease called alopecia, and he thought hey, maybe the worms could fix that.

VELASQUEZ-MANOFF: So I decided to test that proposition.

DOUCLEFF: He went down to Mexico, bought 30 hookworms and let them infect him.

VELASQUEZ-MANOFF: They basically ride your bloodstream back through your heart, into your lungs...

DOUCLEFF: Where they hang out for a while.

VELASQUEZ-MANOFF: ...And they crawl out your lungs, through your stomach and end up in the small intestine.

DOUCLEFF: Where they bite onto the intestinal wall and start sucking blood, a few drops a day. At that point, the worms do something amazing.

P'NG LOKE: The worms suppressed immune systems. That's the really fascinating thing.

DOUCLEFF: That's P'ng Loke, an immunologist at NYU School of Medicine. He says the worms don't shut down the immune system completely, just a little bit so that the immune cells won't attack the worm. But this suppression can help with something else. It keeps the immune system from getting out of control and attacking the body.

LOKE: Yeah. And, I mean, that's really important. If - you know, if you think about it, the worst thing that you want is an immune system that's out of control.

DOUCLEFF: Then you get autoimmune problems - Crohn's disease, allergies, even multiple sclerosis. So the hypothesis is that worms could possibly reverse these problems by damping down the immune system.

The idea was so promising that back in 2011, a pharmaceutical company decided to test it in clinical trials. Coronado Biosciences put together about six large studies. Stephen Hanauer is the medical director of the Digestive Health Center at Northwestern University. He was involved with one of the trials. He says the first study to finish was a big one in Europe. It looked to see if whipworms helped with Crohn's disease. The bottom line...

STEPHEN HANAUER: The proportion of patients who improved with the worms was no different than the proportion of patients who improved with placebo.

DOUCLEFF: The worms didn't work. They were so ineffective that Coronado canceled its other trials, its stock plummeted and, eventually, the company changed its name and its focus. Hanauer says other trials didn't go well either.

HANAUER: The control trials, thus far, in a variety of different diseases, including childhood allergies and asthma, have not been positive.

DOUCLEFF: Back in Berkeley, Velasquez-Manoff got his own results before the news came out about these big trials. He has written about them in a book exploring the therapy. He says a few months after he took the hookworm...

VELASQUEZ-MANOFF: My hay fever was almost completely gone, like, just gone, gone, gone.

DOUCLEFF: And his hair?

VELASQUEZ-MANOFF: And then I had, like, little bit of, like, a peach fuzzy hair growing here and there on my body.

DOUCLEFF: You did?

VELASQUEZ-MANOFF: Yeah.

DOUCLEFF: Wow, it's so interesting.

VELASQUEZ-MANOFF: And then suddenly, it's like, one day, the whole thing reversed.

DOUCLEFF: His hay fever came back. The hair stopped growing, and having the worms in his body wasn't pleasant. He had diarrhea and cramps as long as the worms were inside of him.

VELASQUEZ-MANOFF: I never got back to feeling completely normal for that year.

DOUCLEFF: Is this something that you would use as a therapy?

VELASQUEZ-MANOFF: No. The way I thought of it was, would I give this to my kids? And the answer is pretty easily and obviously, [expletive] no. Like, I wouldn't want them to feel this way.

DOUCLEFF: Michaeleen Doucleff, NPR News. Transcript provided by NPR, Copyright NPR.